by Fiva A Kadi, Tetty Yuniati, Aris Primadi, Sjarif Hidajat and Abdurachman Sukadi
Original Research
Premature birth worldwide still high, in United State was 1-5% and 15.5 in 100 live birth in Indonesia. Premature babies are vulnerable to critically illness especially infections and brain injury. Major problem in brain injury are placed at white matter, in term encephalopaty of prematurity. Ischemic condition will cause glutamate excitation. In many research before have proved that there is correlation between brain and serum glutamate. Intrauterine infection in premature babies have impact to brain with the excretion of pro inflammatory cytokine such as IL-1β. Sample was obtained from 72 premature babies (under 36 weeks GA) birth in June to August 2016 in Hasan Sadikin General Hospital Bandung. This was comparative analysis with cohort approach using logistic regression analysis to determine level of glutamate and IL-1β with minimal sample 63. All premature baby which met inclusion criteria were having blood examination according to algorithm. Median glutamate serum level in premature with encephalopathy higher (67.9g/mL) than premature without encephalopathy (33.9g/mL). Median level of IL-1B serum in premature encephalopathy and sepsis (8,67g/mL) were higher than premature without encephalopathy (12.3g/mL) as well as sepsis (1.7g/mL).It was found/revealed in this study that every increase in a unit of glutamate serum level of a premature neonate means 1.04 times risk to arise encephalopathy, while the increase of IL-1 level in the first 24 hours means 1.33 times risk to arise sepsis with 95% confidence interval..
American Journal of Clinical Medicine Research. 2017, 5(3), 39-42. DOI: 10.12691/ajcmr-5-3-4
Pub. Date: June 15, 2017
10142 Views2765 Downloads
by Deasy Biantong and Hari Soekersi
Original Research
To know the biodistribution of compounds Gadolinium-DOTA-PAMAM dendrimer generation 3.0-Trastuzumab as a necessary ingredient MRI contrast agents in the organs of mice. Biodistribution test using the compound with radioactive marker 125I is injected intravenously into the blood vessel and distributed to the organs of mice were detected by gamma ray count tool. This research method is a descriptive study. Sampling applied with purposive random sampling technique. Research conducted in the laboratory animal center of Radioisotopes and Radiopharmaceuticals Technology National Nuclear Energy Agency (BATAN PTRR), Serpong, Indonesia. Analysis univariable illustrates the biodistribution of compounds Gadolinium-DOTA-PAMAM dendrimer G 3.0-trastuzumab in the organs of healthy mice regarding percentage per gram organ, bivariable analysis to assess differences in the biodistribution of Gadolinium-DOTA-PAMAM dendrimer G 3.0-Trastuzumab in the organs of mice. Biodistribution differences of Gadolinium-DOTA-PAMAM dendrimer G 3.0-trastuzumab injected intravenously in the organs of mice through percentage per gram organs. Percentage per gram organ compounds injected are highest in the blood, the peak accumulation is at 3 hours and declined in 72 hours, the smallest is in the brain. The liver is the largest organ of elimination for the compound (Gd-DOTA)n-PAMAM dendrimer G3.0-Trastuzumab-125I, peak accumulation is at 3 hours and decreased at 72 hours, then the kidney with the highest accumulated peak at 1 hour and declined to 72 hours.
American Journal of Clinical Medicine Research. 2017, 5(3), 36-38. DOI: 10.12691/ajcmr-5-3-3
Pub. Date: June 14, 2017
8975 Views2406 Downloads
by Eddy Fadlyana, Fathiyah Ma’ani, Monalisa Elizabeth and Lelani Reniarti
Original Research
Background Children with thalassemia receiving regular blood transfusions without optimal iron chelation may experience high levels of iron. This condition can cause oxidative stress and affect the certain organs including endocrine organs leading to growth disorders. Objective To determine the correlation between serum ferritin levels and growth disorders in children with thalassemia. Methods This was a cross sectional study conducted during April-May 2015 at Children Thalassemia Clinic, Dr. Hasan General Sadikin Hospital, Bandung. The subjects were collected using consecutive sampling. The subjects were 93 children with thalassemia aged 10–14 years divided into several groups. The study used secondary data taken from the previous studies. The data were analyzed statistically using chi-square test to determine the correlation of both variables. The correlation between serum ferritin levels and growth disorders was examined by using point-biserial correlation and logistic regression models was used to determine the correlation between age and serum ferritin levels with short stature. Results The study included 46 boys (49%) and 47 girls (51%), 62% of which had short statures. The results revealed that the mean serum ferritin level (SD) was 4.355,9 (2.149) μg/L. The correlation between serum ferritin levels and growth disorders (r=-0.260;p=0.012) by ROC value was 3542 μg/L. There was a significant correlation between age and serum ferritin levels with short stature (OR=3.248, CI95%1.304–8.086; OR=3.964, CI95%1.192–13.190). ConclusionThere was significant correlationbetween serum ferritin levels and growth disorders.
American Journal of Clinical Medicine Research. 2017, 5(3), 31-35. DOI: 10.12691/ajcmr-5-3-2
Pub. Date: May 10, 2017
12954 Views3222 Downloads
by Rodman Tarigan, Meita Dhamayanti, Eddy Fadlyana and Kusnandi Rusmil
Original Research
In Indonesia, the prevalence of short stature in adolescents aged 13-15 years and 16-18 years are respectively 35,1% and 31,4%. The growth of adolescentsis related in line to the development with the cognitive function. To find out the difference result of cognitive impairment screening in adolescents aged 10-12 years with normal and short stature. This was a cross-sectional analytic study conducted during December 2016 – March 2017 in Pangandaran District, West Java. Body height of the subjects were measured and they answered questions in Mini–Mental State Examination (MMSE) to assess the cognitive function. Data analysis to determine the different results of cognitive impairment screening in adolescent with normal and short stature use statistical Wilcoxon rank sum test. A total of 144 subjects met the inclusion criteria, comprising 45 subjects with short stature and 99 subjects normal. Median (min; max) MMSE scores for adolescent with short stature and normal were 24 (14; 30) and 27 (9; 30). There were significant differences in the median of MMSE scores between adolescents with normal and short stature (median difference = -2.00, CI 95% (-3.00;-0.00), p = 0.013). There were significantly different results of this study in cognitive impairment screening in adolescents aged 10–12 years between normal and short stature. The result of cognitive impairment screening in short statured adolescents aged 10-12 yearswas lower compared to those of normal stature adolescents.
American Journal of Clinical Medicine Research. 2017, 5(3), 26-30. DOI: 10.12691/ajcmr-5-3-1
Pub. Date: April 19, 2017
11198 Views3313 Downloads9 Likes