American Journal of Clinical Medicine Research

Preeclampsia is a severe disorder of pregnancy characterized by the development of hypertension and proteinuria, increased vascular resistance and endothelial dysfunction in the mother, altered placental perfusion and restricted fetal growth. There is increased release of soluble growth factor like sFlt 1 from placenta, which decreases the availability of Vascular Endothelial Growth Factor(VEGF) receptors and decreases the availability of endothelial Nitric Oxide synthase. This inturn decreases the diastolic relaxation and endothelial dysfunction, podocyte injury of glomerular cells, increased excretion of podocyte specific proteins in urine leads to proteinuria. Cardiac hypertrophy further complicates the heart function. There is a raise in liver function; soluble factor like tyrosine kinase 1 (sFlt 1) may cause a disturbance in thyroid hormone function, thus prone to thyroid problem during or after pregnancy.

American Journal of Clinical Medicine Research. 2014, 2(6), 111-113. DOI: 10.12691/ajcmr-2-6-2
Pub. Date: December 29, 2014

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Adiponectin Correlates in Malaysians: A Comparison of Metabolic Syndrome and Healthy Respondents

by Mohd Aznan Md Aris, Muhammad Muzaffar Ali Khan Khattak, Zamzila Abdullah, Razman Mohd Rus and And Samsul Draman

Original Research

Several studies have demonstrated that adiponectin has strong association with metabolic syndrome and its factors like obesity, insulin resistance, type 2 diabetes, dyslipidemia and coronary artery disease. A total 152 subjects were registered in this study. Among the respondents 76 were with metabolic syndrome (based on the criteria of the International Diabetes Federation (IDF) world-wide definition) and another 76 matching healthy respondents. The factors which were studied for possible differences and association include central obesity (body mass index (BMI) & waist circumference (WC), hypertension (systolic blood pressure (SBP), diastolic blood pressure (DBP), dyslipidemia (total cholesterol (Tc), high density lipoprotein Cholesterol (HDL-c), low density lipoprotein Cholesterol (LDL-c), Triglyceride (TG) and Adiponectin (AD), fasting plasma glucose and history of smoking. The data collected was statistically analyzed using SPSS statistical software version 12.0. Two tests were performed including paired t-test and Pearson correlation analysis. The collected data revealed some interesting differences for the healthy and metabolic syndrome respondents. There were significant (P<0.01) differences for central obesity and hypertension. There were also significant (P<0.01, P<0.1, P<0.01) differences for TG, HDL and fasting plasma glucose. More importantly, AD concentration was significantly (P<0.05) higher in normal healthy respondents. The AD showed strong negative association (r = - 2.91, P<0.001) with FBG and positive association (r = 2.89, P<0.001) with HDL-c. The present study provides baseline information on the predication of metabolic syndrome in Malaysian population.

American Journal of Clinical Medicine Research. 2014, 2(6), 106-110. DOI: 10.12691/ajcmr-2-6-1
Pub. Date: December 28, 2014

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