Correlation between Serum Ferritin Level and Growth Disorders in Children with Thalassemia

Eddy Fadlyana^1, , Fathiyah Ma’ani¹, Monalisa Elizabeth¹ and Lelani Reniarti¹

¹Department of Child Health, Faculty of Medicine Universitas Padjadjaran/Dr. Hasan Sadikin General Hospital Bandung, Indonesia

Cite this paper

Eddy Fadlyana, Fathiyah Ma’ani, Monalisa Elizabeth and Lelani Reniarti. Correlation between Serum Ferritin Level and Growth Disorders in Children with Thalassemia. American Journal of Clinical Medicine Research. 2017; 5(3):31-35. doi: 10.12691/AJCMR-5-3-2

Abstract

Background Children with thalassemia receiving regular blood transfusions without optimal iron chelation may experience high levels of iron. This condition can cause oxidative stress and affect the certain organs including endocrine organs leading to growth disorders. Objective To determine the correlation between serum ferritin levels and growth disorders in children with thalassemia. Methods This was a cross sectional study conducted during April-May 2015 at Children Thalassemia Clinic, Dr. Hasan General Sadikin Hospital, Bandung. The subjects were collected using consecutive sampling. The subjects were 93 children with thalassemia aged 10–14 years divided into several groups. The study used secondary data taken from the previous studies. The data were analyzed statistically using chi-square test to determine the correlation of both variables. The correlation between serum ferritin levels and growth disorders was examined by using point-biserial correlation and logistic regression models was used to determine the correlation between age and serum ferritin levels with short stature. Results The study included 46 boys (49%) and 47 girls (51%), 62% of which had short statures. The results revealed that the mean serum ferritin level (SD) was 4.355,9 (2.149) μg/L. The correlation between serum ferritin levels and growth disorders (r=-0.260;p=0.012) by ROC value was 3542 μg/L. There was a significant correlation between age and serum ferritin levels with short stature (OR=3.248, CI95%1.304–8.086; OR=3.964, CI95%1.192–13.190). Conclusion There was significant correlation between serum ferritin levels and growth disorders.

Keywords

thalassemia, child, ferritin serum, growth disorder, short stature

Copyright

This work is licensed under a Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

References

[1]	De P, Mistry R, Wright C, Pancham S, Burbridge W, Gangopadhayay K, et al. A review of endocrine disorder in thalassemia. Open J Endocr Met Dis. 2014; 4: 25-34.
[2]	Moayeri H, Oloomi Z. Prevalence of growth and puberty failure with respect to growth hormone and gonadotropins secretion in beta-thalassemia major. Arch Iranian Med. 2006; 9(4): 329-34.
[3]	Hoffbrand A, Taher A, Cappellini M. How I treat tranfusional iron overload. Blood J Hematol Libr. 2012: 1-46.
[4]	Spiliotis BE. β-Thalassemia and normal growth: are they compatible?. Eur J Endocr. 1998; 139: 143-4.
[5]	Hashemi, Ghilian, Golestan, Ghalibaf A, Zare, Defghani. The study of growth in thalassemic patients and its correlation with serum ferritin level. Iranian J Pediatr Hematol Oncol. 2011; 1(4): 147-51.
[6]	Andayani SH, Sekarwana N, Fadil R. Association between age and serum ferritin level with bone age deficit in children with thalassemia major. Paediatr Indones. 2008; 48(1): 33-6.
[7]	Majmoodi Nesheli H, Farahanian E. Relation between bone mineral density and serum ferritin levels in patients with thalassemia major. Caspian J Pediatr. 2016; 2(2): 158-63.
[8]	Galanello R, Origa R. Beta-thalasemia. Orphanet J Rare Dis. 2010; 5(11): 1-15.
[9]	Auda R, Idjradinata PS, Djais JTB. Risk factors to growth retardation in major thalassemia. MKB. 2011; 1(43): 21-5.
[10]	Najafipour. Evaluation of endocrine disorders in patients with thalassemia major. Int J Endocrinol Metab. 2008; 2: 104-13.
[11]	Borgna-Pignatti, Gamberini MR. Complications of thalassemia major and their treatment. Expert Rev Hematol. 2011; 4(3): 353-66.
[12]	Jana A, Gupta D, Bhattyacharyya M, Sarkar BN. Correlation between nutritional status and clinical parameters among thalasaemic patients – A study of West Bengal. Human Biology Review. 2016; 5(3): 349-60.
[13]	Shamshirsaz AA, Bekheirnia MR, Kamgar M, Pourzahedgilani N, Bouzari N, Habibzadeh M, et al. Metabolic and endocrinologic complications in beta-thalassemia major: a multicenter study in Tehran. Endocr Dis. 2003; 3(4): 1-6.
[14]	Al-Wataify AS. Growth retardation among multi-transfused thalassemic patients in thalassemia center in Babylon Governorate. Med J Babylon. 2012; 4(9): 815-23.
[15]	Shalitin S, Carmi D, Weintrob N, Philip M, Miskin H, Kornreich L, et al. Serum ferritin level as a predictor of impaired growth and puberty in thalassemia major patients. Eur J Haem 2005; 74: 93-100.
[16]	Jahargirdar R, Parikh S, Deshpande R, Lalwani. Growth profile of children with thalassemia major. Indian J Appl Res. 2017; 7(1): 724-6.