Frequency of Helicobacter Pylori Infection on Histopathology in Patients with Dyspepsia

Shazia Yasir^1, , Faisal Moin¹ and Syed Mamoon Akhtar¹

¹Department of Emergency Medicine, Ziauddin University Hospital, North Campus, Karachi

Cite this paper

Shazia Yasir, Faisal Moin and Syed Mamoon Akhtar. Frequency of Helicobacter Pylori Infection on Histopathology in Patients with Dyspepsia. American Journal of Clinical Medicine Research. 2014; 2(3):53-56. doi: 10.12691/AJCMR-2-3-1

Abstract

Objective: To determine the frequency of Helicobacter Pylori infection on histopathology in patients presenting with dyspepsia. Background: Helicobacter Pylori is associated with dyspepsia in patients who have gastric mucosal abnormalities and this infection can be diagnosed by invasive and non invasive test. Histology of endoscopically taken biopsy, for exploration of this organism is used in this study. Study Design: Cross-sectional, observational study. Place and Duration of Study: Department of Emergency Medicine, Ziauddin University Hospital, Karachi for Six months from March 2013 to August 2013. Methodology: A total of 362 cases with dyspeptic symptoms were underwent an upper gastrointestinal endoscopy after fulfilling the selection criteria. H. Pylori infection would be defined by the presence of dyspeptic symptoms with detection of the bacterium on histopathology. All the data was collected by using a proforma and different parameters were assessed for a minimum follow-up period of one month. Data was analyzed by descriptive statistics using SPSS software version 19. Result: Out of 362 cases of dyspepsia 218 (60.2%) males and 144 (39.8%) females (Male: Female was 1.5: 1). Two fifty one (69.3%) patients with dyspepsia were H. Pylori positive on histopathology. Out of 251 cases having H. Pylori infection 165 (75.7%) were male and 86 (59.7%) female. High percentage was found in the age between 31 – 50 years, 160 (77.3%). Conclusion: In this study 69.3% of the patients examined were H. Pylori positive on histopathology. Male sex and older age (> 30 years) are independent risk factor of H. Pylori infection in dyspeptic patients.

Keywords

dyspepsia, H Pylori, gastric mucosal biopsy, H. Pylori positive gastritis

Copyright

This work is licensed under a Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

References

[1]	Atherton JC, Blaser MJ, Coadaptation of Helicobacter Pylori and humans: Ancient history, modern implications. J, Clin, Invest. 2009; 119.
[2]	Fennerty MB. Helicobacter Pylori: why it still matters in 2005. Cleve Clin J Med. 2005; 72:1-21.
[3]	Lehours P, Yilmaz O. Epidemiology of Helicobacter Pylori infection. Helicobacter. 2007; 12: 1-3.
[4]	Lacy BE, Rosermore J. Helicobacter Pylori: ulcers and more: The beginning of an era. J Nutr. 2001; 131: 2789-93.
[5]	Queralt N, Araujo R. Analysis of the survival of H. Pylori within a Laboratory based aquatic model system using molecular and classical Techniques. Microb, Ecol. 2007; 54: 771-7.
[6]	Khan SS, Zulfiqar A, Danish KF, Sauwal M, Bashir S, Zaman S. Prevalence of H. Pylori infection in patients with gastroduodenal disease in Pakistan. In Railway Hospital, Rawalpindi. Rawal Med J. 2008; 33: 88-9.
[7]	Ferrucci PF, Zucca E. Primary gastric lymphoma pathogenesis and treatment: what has changed over the past 10 years? Br J Haematol. 2007; 136: 521-38.
[8]	Pasceri V, Patti G, Cammarota G, Pristipino C, Richichi G, Di Sciascio G. Virulent strains of Helicobacter Pylori and vascular diseases: a meta-analysis. Am Heart J. 2006; 151: 1215-22.
[9]	Asahi A, Kuwana M, Suzuki H, Hibi T, Kawakami Y, Ikeda Y. Effects of a Helicobacter Pylori eradication regimen on antiplatelet autoantibody response in infected and uninfected patients with idiopathic thrombocytopenic purpura. Haematologica. 2006; 91: 1436-7.
[10]	Concepts in the management of Helicobacter Pylori infection: the Maastricht III Consensus Report. Gut. 2007; 56: 772-81.
[11]	Cutler AF. Testing for H. Pylori in clinical practice. Am J Med. 1996;100:35-41
[12]	Hussain SR, Abbas Z. Presence of Helicobacter Pylori in dyspeptic patients with endoscopically normal stomach. Pak J Med Sci. 2007; 23: 335-9.
[13]	Qasim A, O’ Morain CA. Treatment of Helicobacter Pylori infection and factors influencing eradication. Aliment Pharmacol Ther. 2002.
[14]	Ndububa DA, Agbakwuru AE, Adebayo RA, Olasode BJ, Olaomi OO, Adeosun OA, et al. Upper gastrointestinal findings and incidence of Helicobacter Pylori infection among Nigerian patients with dyspepsia. West Afr J Med. 2001; 20: 140-5.
[15]	Adesanya AA, Oluwatowoju IO, Oyedeji KS, da Rocha-Afodu JT, Coker AO, Afonja OA. Evaluation of a locally-made urease test for detecting Helicobacter Pylori infection. Niger Postgrad Med J. 2002; 9: 43-47.
[16]	Ola SO, Yakubu A, Otegbayo JA, Oluwasola AO, Ogunbiyi JO, Akang EE et al. The most appropriate site for endoscopic biopsy for the detection of H. Pylori among Nigerians in Ibadan. West Afr J Med. 2006; 25: 269-72.
[17]	Ahmed R. Management of dyspepsia.Pak J Med Sci 2004;20:55-60
[18]	Marshall BJ. Helicobacter Pylori. The etiologic agent for peptic ulcer. JAMA 1995;274:1064-6
[19]	Athrton JC, Blaster MJ. Helicobacter infection. In: Favci AS, Brawnwald E, Wilson KG, Martin JB, Kasper DL, et al. Harrison’s Principles of Internal Medicine 1998. p. 941-43.
[20]	Brown KE, Peura DA. Diagnosis of Helicobacter Pylori.Am J Gastroentrol Clin North Am 1993; 22: 105-15.
[21]	Gold Bd, Colletti RB, Abbot M, Cziknn SJ, Elistsur Y, Hassall E, et al. North Amereican Ssociekty for Pediatric Gastroenterologyand Nutriton. Helicobactere Pylori infection in children: Recommendations diagnosis and treatment. J Pediatr Gastroenterol Nutr 2000; 31: 490.
[22]	Lacy BE, Rosemore J. Helicobacter Pylori: Ulcers and more: The beginning of an era. J Nutr 2001; 131: 2789-93.
[23]	Dunn ED, Cohen H, Blaser MJ. Helicobacter Pylori. Clin Microbiol Rev 1997; 10: 720-41.
[24]	Ibrahim BH, Anim JT, Sarkar C. Helicobacter Pylori associated chronic gastritis in Kuwait. Annals of Saudi Medicine 1995; 15: 570-4.
[25]	Shennak MM, Kilani AF. Helicobacter Pylori in dyspeptic Jordanian patients. Trop Gastroenterol 1998; 19: 15-8.
[26]	Bani-Hani KE, Hammouri SM. Prevalence of Helicobacter Pylori in Northern Jordan: Endoscopy based study. Saudi Med J 2001; 22: 843-7.
[27]	Mohamed AE, Al-Karawi A, Al-Jumah A, Ahmed AM, Sharig S, Yasawy MI et al. Helicobacter Pylori: incidence and comparison of three diagnostic methods in 196 Saudi patients with dyspepsia. Hepatogastroenterology 1994; 41:48-50.
[28]	Azim Mirghani YA, Ahmed S, Ahmed M, Ismail MO, Fedail SS, Kamel M et al. Detection of Helicobacter Pylori in endoscopic biopsies in Sudan. Trop Doct 1994;24:161-3
[29]	Hashemi MR, Rahnavardi M, Bikdeli B, Dehghani Zahedani M. H Pylori infection among 1000 southern Iranian dyspeptic patients. World J Gastroenterol 2006; 12: 5479-82.
[30]	Gunaid AA, Hassan NA, Murray-Lyon I. Prevalence and risk factors for Helicobacter Pylori infection among Yemeni dyspeptic patients. Saudi Med J 2003; 24: 512-7.
[31]	Zaitoun AM. Histological study of chronic gastritis from the United Arab Emirates using the Sydney system of classifi cation. J Clin Pathol 1994; 47: 810-5.
[32]	Britt DP, Barakat MH, Tungekar MF, Painchaud SM, Adlouni M, Kern K, Malhas L. Helicobacter Pylori in dyspeptic patients in Kuwait. J Clin Pathol 1990; 43: 987-91.
[33]	Malik MF, Hussain T, Khan MN, Mirza SA, Faroo M. Helicobacter Pylori infection in patients with dyspeptic symptoms having normal endoscopy. PAFMJ. 2010; 1. http://www.pafmj.org/showdetails.php?id=308&t=o.
[34]	Talib A, Shujai M, Mahmood K, Farooqui AN, Mustufa G. Various methods to detect helicobacter pylori and their respective yield. Ann Abbasi Shaheed Hosp Karachi Med Dent Coll. 2005; 10: 698-703.
[35]	Inayatullah M, Arshad M, Nasir SA, Anjum AH, Hussain A. Occurrence of helicobacter pylori in patients presenting with dyspepsia. Pakistan J Gastroenterol 1993; 7: 74-7.