Ribosomal P Antibodies Preceding the Onset of Sle-A Case Report

Prashanth N C, Satyanarayana. N, T. AnilKumar^, and Ravikumar. R

Cite this paper

Prashanth N C, Satyanarayana. N, T. AnilKumar and Ravikumar. R. Ribosomal P Antibodies Preceding the Onset of Sle-A Case Report. American Journal of Clinical Medicine Research. 2013; 1(2):26-27. doi: 10.12691/AJCMR-1-2-1

Abstract

Systemic lupus erythematosus (SLE) is an autoimmune disorder characterized by the Production of auto antibodies directed against a variety of nuclear and cytoplasmic antigens. Auto antibodies to ribosomal Proteins are found in 15–30% of systemic lupus erythematosus (SLE) patients. Ribosomal P antibody is shown to predict SLE 1.7 years before clinical onset of SLE. This is a case of 28 year old female patient with a malar rash and nonspecific neurologic symptoms .The antibody profile showed that ANA ,anti- Ds dna and anti- Sm antibodies were negative but anti ribosomal P0 antibody was strongly positive(+++) at presentation. A strong clinical suspicion and careful follow-up helped in making a diagnosis of SLE over a period of nine months.

Keywords

ribosomal P antibody, SLE, ANA

Copyright

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References

[1]	Harefuah. The clinical importance of anti-ribosomal-P antibodies. 2010 Dec; 149(12):794-7, 810.
[2]	Briani C, Lucchetta M, Ghirardello A, Toffanin E, Zampieri S, Ruggero S, Scarlato M, Quattrini A, Bassi N, Ermani M, Battistin L, Doria A. Neurolupus is associated with anti-ribosomal P protein Antibodies: an inception cohort study. Journal of autoimmunity. 2009; 32:79-84.
[3]	Sato T, Uchiumi T, Ozawa T, Kikuchi M, Nakano M, Kominami R, Arakawa M. Auto antibodies Against ribosomal proteins found with high frequency in patients with systemic lupus Erythematosus with active disease. The Journal of rheumatology. 1991; 18:1681-1684.
[4]	Hasler P, Brot N, Weissbach H, Parnassa AP, Elkon KB. Ribosomal proteins P0, P1, and P2 are Phosphorylated by casein kinase II at their conserved carboxyl termini. The Journal of biological Chemistry. 1991; 266:13815-13820.
[5]	Latisha D. Heinlen Lauren L. Ritterhouse Micah T. McClain Ribosomal P Auto antibodies are Present before SLE Onset and are directed against non-C Terminal Peptides. J Mol Med (Burl). 2010 July; 88(7): 719-727.
[6]	Arbuckle MR, McClain MT, Rubertone MV, Scofield RH, Dennis GJ, James JA, Harley JB. Development of auto antibodies before the clinical onset of systemic lupus erythematosus. N Engl J Med. 2003; 349:1526-1533.
[7]	Heinlen LD, McClain MT, Merrill J, Akbarali YW, Edgerton CC, Harley JB, James JA. Clinical Criteria for systemic lupus erythematosus precede diagnosis, and associated auto antibodies are Present before clinical symptoms. Arthritis and rheumatism. 2007; 56:2344-2351.