Prognostic Significance of Serum Uric Acid at the Time of Admission in Patients with Acute Stroke

Dhrubajyoti Bandyopadhyay^1, , Adrija Hajra², Sabyasachi Mukhopadhyay³, Manas Layek¹, Diptak Bhowmick³, Vijayan Ganeshan³, Sibnarayan Sasmal³, Debarati Bhar³, Cankatikachoudhury³ and Partha Sarathi Karmakar³

¹Department of accident and emergency, Lady Hardinge Medical College, New Delhi

²Department of Internal Medicine, IPGMER, Kolkata

³Department of Internal Medicine, RG Kar Medical College, Kolkata

Cite this paper

Dhrubajyoti Bandyopadhyay, Adrija Hajra, Sabyasachi Mukhopadhyay, Manas Layek, Diptak Bhowmick, Vijayan Ganeshan, Sibnarayan Sasmal, Debarati Bhar, Cankatikachoudhury and Partha Sarathi Karmakar. Prognostic Significance of Serum Uric Acid at the Time of Admission in Patients with Acute Stroke. American Journal of Clinical Medicine Research. 2015; 3(2):24-30. doi: 10.12691/AJCMR-3-2-2

Abstract

Background & objectives: Stroke is the one of the important causes of death.Uric acid is described as a strong endogenous antioxidant that is consumed early in acute stroke. Uric acid being an aqueous antioxidant can become a pro-oxidant under certain circumstances, particularly, if other antioxidants such as ascorbate are low. This work was conducted to find an association between serum uric acid levels at the time of admission with functional outcome in patients with acute stroke. Method: This study was carried out on 96 patients of stroke including both ischemic and hemorrhagic stroke. Sampling scheduled one day of the week by rotation to avoid selection bias and the study design was descriptive, observational, cross-sectional study. Result: we found statistically significant positive correlation between serum uric acid level and change in Mathew score in ischemic stroke patients and poor positive correlation between uric acid level and change of Mathew score in hemorrhagic stroke patients. Conclusion: High serum uric acid level is associated with good neurological outcome in patients with acute ischemic stroke. A high serum uric acid level is associated with insignificant poor neurological outcome in patients with hemorrhagic stroke.

Keywords

acute stroke, mathew score, Uric acid (UA)

Copyright

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